A new, noninvasive test to check the quality of embryos could make a huge difference to people undergoing fertility treatment. Right now, one of the big barriers to success in
“Unfortunately, IVF success still involves a big element of chance, but that’s something we’re hoping our research can change,” said co-senior author H. Irene Su of UC San Diego in a
Since the birth of the
Doctors are under pressure to select the lab-grown embryos that have the best chance of resulting in a healthy pregnancy for each patient, but this is no easy task.
“Right now, the best way we have to predict embryo outcome involves looking at embryos and measuring morphological characteristics or taking some cells from the embryo to look at genetic makeup, both of which have limitations,” Su explained.
The team wanted to look at things a different way. The new method doesn’t examine the embryos themselves, but uses the leftover liquid medium that was used to grow them. It doesn’t involve any extra steps and doesn’t interfere with the
While cells are growing, they release small molecules of
“It’s really only in the last decade that we have started to uncover the uses for exRNAs, and there could be countless other applications we haven’t yet discovered,” said co-senior author Sheng Zhong.
The team took samples of growth medium from
The model’s predictions were found to match up with the tests that are currently used to check for
The authors caution that it will be some time before any new method can be used in a clinical setting. “We have data connecting healthy morphology to positive IVF outcomes, and now we’ve seen that exRNAs can be used to predict good morphology, but we still need to draw that final line before our test will be ready for primetime,” said Su.
But it’s a promising start, and an innovative way of addressing an old problem.
As Su put it, rather than targeting the embryos directly, “What we’ve done is more akin to looking at what’s left behind at an archeological site to help us learn more about who lived there and what they did.”
The study is published in