Meet Qizai: not only is he thoroughly
A team of researchers set out to determine whether any differences in the
In comparing the resulting sequences, the team identified what they believe to be the gene involved: Bace2. This gene encodes an enzyme that’s involved in chopping up
The brown pandas were found to have two identical copies of a particular variant of Bace2, both missing 25 base pairs (the building blocks of DNA, often simply represented by letters), suggesting it could play a role in their fur color.
The researchers didn’t stop there though. In search of validation for their findings, they also sequenced the DNA of another 192 black and white pandas, with the analysis revealing that none had two copies of that same variation in Bace2. When they further created mice with the mutation, using a method called
But how does this mutation lead to brown pandas like Qizai?
“Our investigation revealed that this mutation reduced the number and size of melanosomes of the hairs in knockout mice and possibly in the brown panda, further leading to the hypopigmentation,” the researchers write in their paper.
Melanosomes are specialized structures within cells – the fancy term being organelles – responsible for the production and storage of
Thus, a mutation in Bace2 might affect melanosomes in pandas, and consequently give them brown and white fur instead of black and white. The next step for the researchers is to investigate this theory and figure out how it might work – Qizai is still keeping some cards close to his chest.
That being said, the current research is a pretty big first step in solving the puzzle of these rare pandas. Qizai the brown
The study is published in the journal