It’s hard not to love octopuses – they’re bizarre-looking, hugely
Scientists back in the 1970s had linked the death spiral to the octopus
Fast forward to 2022, and it turns out Wodinksy was at least partially right. Researchers with the University of Chicago set to analyzing the chemicals secreted by the maternal octopus optic gland, focusing in on cholesterol and sterol hormones. Previous studies by the team suggested these molecules could play a role.
The researchers discovered that the optic gland in maternal
“What’s striking is that they go through this progression of changes where they seem to go crazy right before they die,” said study author Clifton Ragsdale in a
One of these pathways results in increased levels of 7-dehydrocholesterol (7-DHC), a precursor molecule to cholesterol. In humans, a mutation in the enzyme that’s involved in this conversion leads to a genetic disorder that can involve repetitive self-injury. That makes this finding particularly pertinent, as some octopuses display
While the study provides long-awaited insight into how the death spiral is controlled, it remains that this tragic process doesn’t happen in every
“The optic gland exists in all other soft-bodied cephalopods, and they have such divergent reproductive strategies,” said Wang. “It’s such a tiny gland and it’s underappreciated, and I think it’s going to be exciting to explore how it contributes to such a great diversity of life history trajectories in cephalopods.”
The study is published in