A 30-year study of over 900 participants has found an association between polycystic ovary syndrome (PCOS) and problems with memory and cognition. While it’s not possible to say for sure that PCOS caused the observed issues, the scientists behind the work say more research is now needed to better understand these potential risks of a condition that many struggle with for years before getting a diagnosis.
The
As the name suggests, one of the symptoms of
Quite apart from the debilitating physical symptoms, many people with PCOS also experience negative psychological impacts from the disease, including depression and poor body image.
Now a new study, which followed 907 female participants for 30 years, has uncovered a possible link between PCOS and problems with memory and cognition in middle age.
Study author Dr Heather G. Huddleston of the University of California San Francisco explained in a
“Our results suggest that people with this condition have lower memory and thinking skills and subtle brain changes at midlife. This could impact a person on many levels, including quality of life, career success and financial security.”
The participants were aged between 18 and 30 years old at the start of the study period. After 30 years, at which time 66 members of the study group had PCOS, they were asked to complete tests of memory, verbal ability, processing speed, and attention.
One of the tests for attention was the
Overall, scores in three of the tests – focusing on memory, attention, and verbal abilities – were lower for those with PCOS, after adjusting for age, race, and education.
As well as the cognitive tests at year 30, a subgroup of the participants (291, of whom 25 had PCOS) also received brain scans at years 25 and 30. The scans revealed lower
The study has some limitations, in particular the fact that the PCOS diagnoses were not made by a doctor but were based on tests of the patients’ hormone levels and their self-reported symptoms. It’s also not possible from these data to say definitively that PCOS caused the cognitive and brain changes observed, but the researchers believe there’s enough here to warrant further investigation.
“Additional research is needed to confirm these findings and to determine how this change occurs, including looking at changes that people can make to reduce their chances of thinking and memory problems,” said Huddleston.
“Making changes like incorporating more cardiovascular exercise and improving mental health may serve to also improve brain aging for this population.”
The study is published in the journal