For the first time, a non-human animal has demonstrated the ability to recall events from their past and use them to answer an unexpected question. The breakthrough comes after the possibility was first explored six years ago and could potentially unlock new treatment avenues for patients with memory loss.
Episodic
We know from studies that
“Using rats can help further the field of memory by providing a way to identify and measure behavioral patterns and changes that are more sophisticated and complex than mouse models, as well as model diseases like Alzheimer’s to test treatments before they reach the clinical stages,” Sheridan explained in a
Working with Professor Jonathon Crystal, who also supervised the 2018 study, Sheridan and colleagues created an experiment that would require the rats to use not only their episodic memories, but also their
First, the nine rats were presented with a selection of common spices one by one, including
The rats were then put into a radial maze that contained spice containers with scented lids. After sniffing around the maze, they were once again given the chance to identify the third-to-last scent from the original list.
The researchers only had to run the experiment once: every single rat answered the question correctly after their time in the maze, giving a success rate of an astonishing 100 percent.
“What we wanted to test is a property of what people do in everyday life that has never been shown in a non-human animal,” said Crystal. “We remember information even though it was seemingly unimportant when it was encountered. When we happen to need that information, we replay the stream of events to identify the information needed to solve our current problem.”
The findings not only tell us more about the impressive cognitive abilities of rats, but they could also have important implications for research into human disease. Many drugs for
“What you really want to know when you test Alzheimer’s patients is that there is relief in remembering that their granddaughter visited last week and talked about interesting things going on in her life. Those are the things that are going to produce huge societal changes when the drugs are effective, not just at general aspects of memory but specifically targeting episodic memory.”
The study is published in the journal